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Bupropion XL, which allows for once-daily dosing up to 450 mg, was approved for the. to 8 weeks of therapy with bupropion SR (150 mg b.i.d.) were randomly assigned in a. Lastly, bupropion has been studied for its effects on weight loss. Lets dig into how Wellbutrin helps with weight loss and determine if its. If you are only 150 pounds, its possible that Wellbutrin only. If you want to combine this with Naltrexone then that dosage ranges. The only reason to reduce the dose or to switch to XL is if you are having issues with sleep. No nausea, no headaches, no weight loss or gain. distributed by EON bupropion hcl SR 150mg and tried wellbutrin xl 150mg. Foxbluff HB User. Re wellbutrin xl and weight loss. Now Im on Wellbutrin XL 150 mg twice a day, and I feel damn good. I havent lost any.